Abstract
Purpose: Effective cancer brachytherapy requires a treatment plan that delivers high dose to tumor while minimizing dose to critical normal tissue. Current planning systems generate accurately physical dose distributions but do not take biological effects into account. In an effort to incorporate modeling of biologic dose effects into paradigms based on physical dose distributions, this study was undertaken with specific aims of (1) developing optimization schemes to produce high dose rate (HDR) remote afterloading treatment plans using both biological model and physical dose based objectives and (2) determining the feasibility of performing HDR treatment planning based on biological models.
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