Abstract
Statistical Optimization of Olanzapine Ternary Solid Dispersions with Pvp K 30 and Peg 20,000 by Response Surface MethodologyAnil Katharia, Ratendra Kumar, Rajiv Sharma, Yogendra Singh, Uday Veer Singh Teotia
Highlights
Antithrombin is a glycolprotein having 432 amino acid residues, 4 glucosamine-based oligosaccharide side units, and 3 disulfide bridges (Franzen et al, 1980 and Petersen et al, 1979)
This work, for the first time reports the optimization of recombinant human antithrombin production in Saccharomyces cerevisiae BY4741 using statistical experimental designs
Yeast nitrogen base (YNB) without uracil, aspartic acid, Raffinose, Galactose, complete supplement mixture and vitamin mix were procured from Himedia, India
Summary
Antithrombin is a glycolprotein having 432 amino acid residues, 4 glucosamine-based oligosaccharide side units, and 3 disulfide bridges (Franzen et al, 1980 and Petersen et al, 1979) It is produced in the liver and has a plasma level of approximately 150 mg/L (Murano et al, 1980). Antithrombin acts mainly as the most significant plasma inhibitor of thrombin and antithrombin has strong inhibitory effects on variety of active serine proteases, including IXa, Xa, Xia, XIIa, and FVIIa factors (Damus et al, 1973 and Travis et al, 1983). This is demonstrated by the fact that individuals with. The use of recombinent proteins at a commercial scale is constrained by the ability to gain the product in higher yields from microbial processes (Freigassner et al, 2009).
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