Abstract
Meeting abstracts Adoptive transfer of ex vivo expanded neu specific polyfunctional T-cells secreting TNF-alpha (α), IFN-gamma (γ), and IL-17 (Th1/Th17) cells into tumor bearing mice can result in complete resolution of disease as compared to the use of neu specific Th1 (Lai et al 2009). Murine
Highlights
Adoptive transfer of ex vivo expanded neu specific polyfunctional T-cells secreting TNF-alpha (a), IFNgamma (g), and IL-17 (Th1/Th17) cells into tumor bearing mice can result in complete resolution of disease as compared to the use of neu specific Th1 (Lai et al 2009)
Murine antigen specific Th1/Th17 cells could be readily expanded with IL-2 and IL-21 in culture, the use of these cytokines resulted in successful expansion of human tumor antigen specific T-cells in only a minority of patients
PBMC, derived from the aphaeresis of patients previously immunized with a HER2 vaccine, were stimulated with HER2 peptides in the presence of different cytokines to polarize Th17 cells, and cultured with different T-cell growth factors on Day4/8, and subsequently expanded with CD3/CD28 beads on Day 12 and IL-2 for 12 days
Summary
Adoptive transfer of ex vivo expanded neu specific polyfunctional T-cells secreting TNF-alpha (a), IFNgamma (g), and IL-17 (Th1/Th17) cells into tumor bearing mice can result in complete resolution of disease as compared to the use of neu specific Th1 (Lai et al 2009). Optimization of ex vivo expansion of HER2 specific polyfunctional Th1/Th17 cells from HER2 vaccine primed PBMC Yushe Dang*, Lupe Salazar, Jennifer Childs, Doreen Higgins, Mary L Disis
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