Abstract
To maximize the production of virginiamycin (VM and VS) which is commercially used as an antibiotic mixed in animal feed, an empirical approach was employed in the batch culture of Streptomyces virginiae. Here, effects of Dissolved Oxygen (DO) concentration and/or DO supplying condition such as pure oxygen supply and agitation speed changes on the maximum cell concentration at the production phase as well as production activity of virginiamycin were investigated. In order to keep DO concentration in the fermenter at a certain level, either agitation speed or inlet oxygen concentration of supplying gas can be manipulated. It was found that the increase of agitation speed gave positive effect on antibiotics productivity apart from the controlled DO concentration. Optimum DO concentration and agitation speed including VB-C addition was determined for maximize virginiamycin production.
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