Optimization of cultural conditions for biomass and antibacterial metabolite production by Aspergillus fumigatus strain MF1

Abstract

The interest of this work is to study the optimized conditions for antibacterial secondary metabolites from the fungus Aspergillus fumigatus strain MF1 extract. The secondary metabolites such as alkaloids, phenols, terpenoids, toxins and ketones are fascinating in the growth of antimicrobial performance of derived compound from strain MF1 extract in addition to the production of biomass. Hence, there is a need to optimize the conditions like temperature, salt concentration, radiation and pH of culture media to enhance the production of biomass and antibacterial metabolite. However, in this study, the authors examined the antibacterial performance of eight bacterial isolates and results showed that Potato dextrose broth (PDB) for seven days incubation at 30 ​°C temperature, pH-6, maltose (carbon source), yeast extract (nitrogen source), and 5% NaCl is the optimized parameters for high yielding of biomass and antibacterial secondary metabolites by A. fumigatus MF1 extract.