Abstract
Cancer is a leading cause of death and a cost burden on healthcare systems worldwide. The mainstay of treatment is chemotherapy which is most often administered empirically. Optimizing the frequency of drug administration would benefit patients by avoiding overtreatment and reducing costs. In this work, the optimization of chemotherapy regimens using mathematical programming techniques is demonstrated by developing a simple mathematical programming model for the administration of a fictitious drug. The question to be answered by the solution of the model is how often the drug should be administered so that the tumor size does not exceed a predefined size and the treatment cost reaches a minimum value. The proposed mathematical programming model is computer-implemented using a well-established mathematical programming system, thus keeping the cost and effort of obtaining the optimization results low. An example is used to demonstrate the superiority of the proposed optimization approach over the mainstay approach.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
