Abstract
Optimization of camptothecin production and biomass yield from endophytic fungus Fusarium solani strain ATLOY-8
Highlights
Camptothecin (CPT) is a naturally occurring alkaloid.This alkaloid has the ability to prohibit the topoisomerase I; it is an anticancer compound (Hsiang et al, 1988; Kjeldsen et al, 1992; Thomas et al, 2004)
The Box–Behnken design (BBD) exhibited 1.4- and 1.2-fold increase of CPT production and biomass yield, respectively, compared to one factor at a time (OFAT) approach in the basal medium containing absolute ethanol (5%), glucose (1%), and precursors
The endophytic fungus F. solani strain ATLOY-8 was successfully isolated from C. fragrans using morphological and molecular characterization tools
Summary
Camptothecin (CPT) is a naturally occurring alkaloid. This alkaloid has the ability to prohibit the topoisomerase I; it is an anticancer compound (Hsiang et al, 1988; Kjeldsen et al, 1992; Thomas et al, 2004). CPT has derivatives such as topotecan and irinotecan which are used in the medication of colon and ovarian cancers (Demain and Vaishnav, 2011). The demand for CPT per year is approximately 3,000 kg in the international market and the annual production throughout the globe is only 600 kg which cannot meet the demand (Raveendran, 2015). CPT has been spotted in species of plants from unrelated classes of Asterids and Rosids, families, such as Icacinaceae (Pyrenacantha klaineana and Merrilliodendron megacarapum), Gelsemiaceae
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