Abstract
AbstractThe quinolone antibacterial agent cinoxacin was studied by adsorptive stripping voltammetry making use of its controlled interfacial accumulation on a static mercury drop electrode. Measurements were obtained in differential pulse mode and optimized by experimental design. The chemometric approach allowed the identification of a strong interaction between pH and pulse amplitude. The dynamic linear range of calibration was extended from 0.4 to 9 × 10−8 M. Analyses of cinoxacin capsules and spiked human urine sample were carried out without the need of previous extraction or filtration. A cleanup procedure was required to separate cinoxacin from the human plasma matrix prior to adsorptive stripping analysis.
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