Abstract
Objective: Transdermal patch of timolol maleate was prepared in order to increase the permeability of the drug topically.
 Methods: The timolol maleate (TM) loaded solid lipid nanoparticles (SLN) were prepared by the solvent evaporation method. For the optimization process full factorial (three-factor and three-level), hydroxypropyl methylcellulose (HPMC) range from 100 to 300 mg, ethylcellulose 100 to 200 gm and almond oil 3 to 4 ml. The response noted in form of tensile strength and percent drug release. These transdermal patches were evaluated for physical characterization like weight variation, thickness, percentage moisture absorption, percentage moisture loss, water vapor transmission rate, folding endurance, tensile strength, and content uniformity.
 Results: Solid lipid nanoparticles of TM were optimized and prepared, the data presented that drug release percent ranged from 66.12 to 91.75. 2FI model was observed to fit for response % drug permeation with a p and F value of 0.0271 and 4.50. The tensile strength varies from 0.358 to 0.508. The linear model was observed to fit for the tensile strength response with a p-value and F-value of<0.0001 and 52.41.
 Conclusion: The controlled release formulation of Timolol Maleate was successfully optimized and prepared, a study conducted to investigate the effect of different polymers and type of permeation time profiles from Timolol Maleate patches.
Highlights
Cardiovascular disease (CVD) is viewed as multifactorial in origin
In order to prepare Solid Lipid Nanoparticles (SLN) of timolol maleate (TM), the weighed quantity of Lutrol F68 and tween 80 are added to purified water under stirring to get a clear solution and the temperature maintained at 85-90 °C (5% overages of purified water taken to compensate loss on heating), Compritol 888 ATO is heated to melt to this Timolol maleate is added under stirring to get a clear
Timolol maleate transdermal patches were prepared by using the solvent casting technique
Summary
Cardiovascular disease (CVD) is viewed as multifactorial in origin. Because of the contributions of numerous elements, is influenced by different kinds of disorder. 1990, has expressed it [1] that there are contributions of in excess of 250 risk factors have been related to cardiovascular disease Out of those risk factors, the fundamental reasons for the episode of cardiovascular ailments are viewed as inherited, age and gender. It is mainly influenced by the individual way of life and its method of living. The major risk factors associated with cardiovascular disease remain to increase in blood pressure and high blood fats along Aside from these factors, way of life with an ordinary intake of smoking and tremendous utilization of saturated fats causes distinctive kinds of cardiovascular disease. It is a result of less physical idleness or exercise [2]
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