Optimization And Evaluation Of Prazosin Hydrochloride Floating Microspheres Using Response Surface Methodology

Abstract

The purpose of the present study was to get the floating microspheres of Prazosin hydrochloride and to sustain the drug to overcome the side effects as postural hypotension.A central composite design based on the response surface method was used.The preparations were made by emulsion-solvent evaporation method.In this study, a three-factors, three levels Central composite design with drug-polymer ratio (X1), Solvent ratio (X2) and Speed (X3) as independent variables were chosen for the formulation. The microspheres were evaluated for physicochemical parameters as shape, size, buoyancy percentage and drug entrapment efficiency. SEM studies showed good topology of microspheres. The cumulative % drug release of optimized formulation after 24 hours was 99.87%. Model fitting analysis revealed the release pattern followed Korsmeyer.The results demonstrated a good relationship between the predicted and experimental values, supporting the validity of the model.FTIR and DSC studies showed that there was no interaction between drug and polymers. The optimized formulation was found to be stable when subjected to accelerated stability studies. The results obtained indicated that response surface methodology may be successfully used to analyze the effect of formulation variables and develop an optimized formulation thereby reducing the severaltrials, time and cost of formulation development.