Abstract
Evolutionary optimization principles are applied to explain the catalytic efficiency of single enzymes as well as the structural design of metabolic pathways. Special results concern (1) the optimal values of elementary rate constants of enzymatic mechanisms as functions of the external substrate and product concentrations; (2) the distribution of enzyme concentrations in metabolic pathways for states of maximal fluxes, and (3) the optimal distribution of ATP consuming and ATP producing reactions in glycolysis. Conclusions are drawn for the distribution of flux control coefficients resulting from optimization processes.
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