Optimisation of Medical Management of Chronic Rhinosinusitis

Abstract

Chronic rhinosinusitis (CRS) is a common condition and can have a significant impact on quality of life for affected patients. The aetiology is poorly understood leading to the use of a variety of medical treatments to manage the condition, some with little evidence to suggest any benefit. Over the last 3 years, research has been carried out investigating alternatives and alterations to many of the current treatment options for CRS. Of these, alternative delivery methods for intranasal corticosteroids and immunomodulation with monoclonal antibodies show the most promise to improve medical treatment of CRS. CRS can be a difficult to manage condition with multiple treatment options available; however, many of these have a poor evidence base to support their use. When medical management fails, patients can be subjected to debilitating symptoms and repeated endoscopic sinus operations. New treatments which prevent this cycle could revolutionise current management.