Abstract
ABSTRACT Loading of Ferula assa-foetida essentialoil on PLGA nanoparticles for improve its biological activity. FAFEO-PNP were produced by W1/O/W2 method and aftercharacterization, its antibacterial (Disc Diffusion, MIC, MBC), antioxidant(ABTS, DPPH, FRAP), pro-apoptotic (MTT, qPCR, AO/PI staining, Flow cytometery) andanti-angiogenic (CAM) effects were investigated. Cancer induction was performedto evaluate the antitumor effects of FAFEO-PNP. FAFEO-PNP (size: 203.62 nm, PDI: 0.26 and ζ-p: -32.92 mV) inhibited HepG2 (IC50: 57μg/mL) cells. FAFEO-PNP induced the cell death by up-regulation of P53, TNF-α, P-21, Cas-3 and 9 genes. The activity of inhibitingfree radicals and inhibiting the growth of different strains of bacteria in thepresence of nanoparticles showed the antioxidant and antibacterial power of FAFEO-PNP. In vivo analysis including CAMand cancer induction assay confirmed the anti-angiogenic (reduction of vascular parametric factors)and anti-tumor effects of FAFEO-PNP. FAFEO-PNP can be considered as an anti-cancer agent in cancer therapy.
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