Abstract
The characterisation of biomaterials for cardiac tissue engineering applications is vital for the development of effective treatments for the repair of cardiac function.
Highlights
The ability to direct adult stem cells into a speci c lineage of cells is of high interest for tissue engineering, for instance for repairing cardiac function a er the event of a myocardial infarction (MI)
In this study we investigate the control of surface properties of conductive polymers through a systematic approach to variable synthesis parameters, and how the resulting surface properties influence the viability of cardiac progenitor cells
This study shows that the three dopants used during the PPy synthesis will produce variable but controllable changes of the physical properties of PPy materials
Summary
The ability to direct adult stem cells into a speci c lineage of cells is of high interest for tissue engineering, for instance for repairing cardiac function a er the event of a myocardial infarction (MI). The comparatively large increase in monomer concentration to 0.7 M Py (with the same concentration of DBS) produced a surface with ‘wormy’ structures that would contribute to the polymer's high roughness value (189 Æ 25 nm). These measurements indicate that the high roughness values for these materials with high dopant concentration is a contributing factor to the increase in the contact angle.
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