Abstract
Optimal Use of Biomarkers in Oncology: Expression of Activation-induced Cytidine Deaminase (AID/AICDA) in Follicular Lymphoma
Highlights
Follicular lymphoma is a representative indolent lymphoma
We previously reported that activation-induced cytidine deaminase (AID/ AICDA), postulated to be necessary for c-myc translocation, was closely related with the proliferation of follicular lymphoma cells and aggravation of clinical manifestations [6]
There is a rare case report that translocation of both bcl-2 and c-myc was simultaneously detected in the pathohistological diagnosis of follicular lymphoma [22], bcl-2 translocation occurs in the bone marrow and c-myc translocation is a genetic abnormality occurring at the germinal center of peripheral lymph nodes [23]
Summary
We previously reported that activation-induced cytidine deaminase (AID/ AICDA), postulated to be necessary for c-myc translocation, was closely related with the proliferation of follicular lymphoma cells and aggravation of clinical manifestations [6]. Genetic abnormalities related with the advancement of follicular lymphoma, including those in our findings, are outlined with a focus on the c-myc and AID genes in this review. When follicular lymphoma is transformed into diffuse large cell B-cell lymphoma, most cases harbor genetic expression of germinal center-type B-cell lymphoma and maintain bcl-2 expression [12,13].
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