Abstract
BackgroundMetabolic syndrome (MetS) is regarded as a major risk factor for diabetes mellitus and cardiovascular disease (CVD). The optimal threshold of the homeostasis model assessment of insulin resistance (HOMA-IR) has been established for predicting MetS in diverse populations and for different ages. This study assessed the serum HOMA-IR level in a healthy Chinese population aged ≤45 years to determine its relationship with metabolic abnormalities.MethodsCross-sectional study data were collected from health checkup records of Chinese adults aged ≥18 years between 2013 and 2016 at Xiamen Chang Gung Hospital. Participants completed a standardized questionnaire, which was followed by a health examination and blood sample collection. Exclusion criteria were as follows: history of known CVDs; liver, kidney, or endocrine diseases or recent acute illness; hypertension; hyperlipidemia; and pregnancy or lactation.ResultsThe clinical and laboratory characteristics of 5954 men and 4185 women were analyzed. Significant differences were observed in all assessed variables (all P < 0.05). The optimal cutoff point of HOMA-IR for predicting MetS was 1.7 in men and 1.78 in women.ConclusionsWe aimed to determine the optimal cutoff point of HOMA-IR for predicting MetS in a healthy Chinese population aged ≤45 years. The findings of this study would provide an evidence-based threshold for evaluating metabolic syndromes and further implementing primary prevention programs, such as lifestyle changes in the target population.
Highlights
Metabolic syndrome (MetS) is a cluster of factors that include hypertension, obesity, dyslipidemia, and glucose intolerance
Basic Characteristics of the Study Subjects According to Gender
The area under the curve (AUC) of TG/high-density lipoprotein (HDL) (AUC 0.86, cutoff point 1.47) in men was a better predictor of cardiometabolic risk factors than that of other variables
Summary
Metabolic syndrome (MetS) is a cluster of factors that include hypertension, obesity, dyslipidemia, and glucose intolerance. The presence of MetS or insulin resistance (IR) is related to type 2 diabetes and cardiovascular disease (CVD) [2, 3]. IR plays a major role in a cluster of metabolic features, such as obesity, fat distribution in the abdomen, elevated total cholesterol (T-CHOL), triglyceride (TG), and low high-density lipoprotein (HDL) levels and high blood pressure (BP). This cluster of cardiovascular risk factors is referred to as MetS [3, 9]. Metabolic syndrome (MetS) is regarded as a major risk factor for diabetes mellitus and cardiovascular disease (CVD). This study assessed the serum HOMAIR level in a healthy Chinese population aged ≤45 years to determine its relationship with metabolic abnormalities
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