Abstract
IN TREATING adrenal cortical insufficiency it is desirable to ascertain the level of replacement therapy required to substitute completely for the functional activity of normal adrenal cortices. It is common to judge either the animal or the patient as physiologically normal in respect to adrenal cortical function whenever life is maintained and the proportions of water and crystalloids of the blood are within normal limits. There is ample evidence that the requirements for complete replacement therapy by cortical hormones are far greater than is commonly judged to be the case on the basis of these criteria. The purpose of this paper is to consider briefly a few of the laboratory studies relative to this problem. For the reason that the experience of the writer is limited to the laboratory, discussion of therapy in patients is omitted. Ingle and Higgins (1) observed that when one adrenal gland of the rat was enucleated and the contralateral gland was removed there was rapid regeneration of the enucleated ...
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