Abstract
Purpose: We have reported that the Myocor Coapsys device treated functional mitral regurgitation (MR) by reducing mitral annular dimension and repositioning papillary muscles. This study was conducted to evaluate the optimal Coapsys device size. Methods: The Coapsys device was implanted in 7 dogs after induction of MR by rapid ventricular pacing. The device consists of anterior and posterior pads connected by a sub-valvular chord. The device was tightened in 5% increments of the left ventricular (LV) epicardial dimension up to 40%. Hemodynamic and echocardiographic measurements were obtained at each tightening level. RESULTS: There was a significant MR reduction with tightening the device. Although LV end-diastolic volume (EDV) decreased significantly, forward stroke volume (SV) was maintained through the 35% tightening level. Mean aortic pressure (AoP) decreased slightly but significantly. There was no significant change in left atrial pressure (LAP). Conclusion: The Coapsys device can be applied over a broad range of tightening levels without negative physiologic impact. This facilitates use of the device in a variety of clinical setting.Figure
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