Abstract
Optimal International Normalized Ratio for Warfarin Therapy in Elderly Korean Patients with Non-Valvular Atrial Fibrillation
Highlights
Atrial fibrillation (AF) is a common and serious arrhythmia that is frequently associated with the development of stroke and systemic embolism
We investigated the efficacy and safety of low-intensity warfarin therapy in elderly Korean patients with nonvalvular atrial fibrillation (AF) (NVAF)
Ischemic stroke and systemic embolism occurred in 20 patients with international normalized ratio (INR) between 1.00 and 2.44 (16 ischemic strokes and 4 systemic embolisms) and major bleeding in 37 patients with INR between 1.74 and no coagulation
Summary
Atrial fibrillation (AF) is a common and serious arrhythmia that is frequently associated with the development of stroke and systemic embolism. Japanese guidelines recommend INR control between 1.6 and 2.6 in patients who are ≥70 years old because old age is associated with the occurrence of severe bleeding events.[5] In addition, hemorrhagic stroke occurs more frequently in Asian patients than in Caucasians.[5] the efficacy and safety of low-intensity warfarin therapy in elderly Korean patients with NVAF is unknown. We investigated the optimal INR target range and the risks of stroke, systemic embolism, and major bleeding based on age in Korean patients with NVAF. Optimal international normalized ratio (INR) in elderly atrial fibrillation (AF) patients at higher risk of hemorrhagic events remains unclear. We investigated the efficacy and safety of low-intensity warfarin therapy (target international normalized ratio [INR], 1.6–2.6) in elderly Korean patients with nonvalvular AF (NVAF). Conclusion: Low-intensity warfarin therapy (INR, 1.6-2.6) should be considered in elderly Korean patients with NVAF
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