Optimal frequency for vibrational optical coherence elastography (OCE) on tissue mechanical properties characterization

Abstract

Pathological change tends to alter tissue mechanical properties, e.g. tissue stiffness. Current elastography technology use tissue stiffness as a signature to diagnose and localize diseases. Our team focus on vibrational optical coherence elastography (OCE) for its capability to increase signal to noise ratio as well as its high resolution comparing other elastography modalities. The result highly relies on the stimulation frequency for vibrational mode might change as frequency varies. A proper frequency range is required however, there hasn’t been a consensus among the research groups. In order to find the proper frequencies, several parameters measured from real experiment are input in transient model of ANSYS to simulate vibrational pattern of the sample with driving frequencies vary from 100Hz to 1000Hz. An upper limit of frequency has been discovered finally.