Abstract
AbstractThe aim of this paper is to determine the optimal time-dependent control of diluant adding in a diafiltration process that is designed to purify and to concentrate human albumin. We address the control of wash-water utilization in a more general and fundamental form than any previous attempts. Instead of considering arbitrarily constructed schemes, we determine the optimal time-dependent profile of the diluant flow for the entire process by employing optimal control methods. The paper addresses two problems of optimal process operation: (1) the minimization of process time, and (2) the minimization of applied diluant volume. Control vector parametrization approach is applied considering different parametrized forms of the control function such as constant, linear, and piece-wise constant schemes.
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