Optimal control application to the epidemiology of HBV and HCV co-infection

Abstract

It is very important to note that a mathematical model plays a key role in different infectious diseases. Here, we study the dynamical behaviors of both hepatitis B virus (HBV) and hepatitis C virus (HCV) with their co-infection. Actually, the purpose of this work is to show how the bi-therapy is effective and include an inhibitor for HCV infection with some treatments, which are frequently used against HBV. Local stability, global stability and its prevention from the community are studied. Mathematical models and optimality system of nonlinear DE are solved numerically by RK4. We use linearization, Lyapunov function and Pontryagin’s maximum principle for local stability, global stability and optimal control, respectively. Stability curves and basic reproductive number are plotted with and without control versus different values of parameters. This study shows that the infection will spread without control and can cover with treatment. The intensity of HBV/HCV co-infection is studied before and after optimal treatment. This represents a short drop after treatment. First, we formulate the model then find its equilibrium points for both. The models possess four distinct equilibria: HBV and HCV free, and endemic. For the proposed problem dynamics, we show the local as well as the global stability of the HBV and HCV. With the help of optimal control theory, we increase uninfected individuals and decrease the infected individuals. Three time-dependent variables are also used, namely, vaccination, treatment and isolation. Finally, optimal control is classified into optimality system, which we can solve with Runge–Kutta-order four method for different values of parameters. Finally, we will conclude the results for implementation to minimize the infected individuals.