Abstract
A study of the oxidation of palmitate-1-C 14 to C 14O 2 by heart homogenates was undertaken and the optimal conditions were determined. The system has an absolute requirement for carnitine, CoA, ATP, and Mg 2+. The levels of ATP and Mg 2+ for the optimal rate of palmitate oxidation are interdependent. Excess of ATP or Mg 2+ inhibits the production of CO 2. The amount of fatty acid oxidized is dependent on the molar ratio of fatty acid to albumin in the incubation medium: an optimal ratio of approximately 5 was found for all the concentrations of fatty acid and albumin tested. A tentative mechanism for the albumin effect is presented.
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