Abstract
For reasons of time, this short talk will be confined to the optimal frequency, timing, indications and dosing of blood transfusion [...]
Highlights
Blood transfusion protocols in thalassaemia syndromes are more increased risk of allo-immunisation or infection, requirement for widely agreed (1) than for sickle disorders but questions still better venous access for adequate blood flow, and requirements for remain about optimal Hb levels, timing and frequency
For example in HbEβ thalassaemias, the right e shifted oxygen dissociation curve tends to lead to better oxygen s delivery per gram of Hb than in β thalassaemia intermedia with u high Hb F
Recent work by our group (3) suggests that patients with higher levels of endogenous erythropoiesis, marked by higher m levels of soluble transferrin receptors, at significantly lower risk of o cardiac iron deposition than in those where endogenous erythroc poiesis is less active, as would be the case in transfusion regimes - achieving higher levels of pre-transfusion Hb. n In sickle cell disorders, the variability in the phenotype between patients and within a single patient at any given time o means that the need for transfusion varies
Summary
Blood transfusion protocols in thalassaemia syndromes are more increased risk of allo-immunisation or infection, requirement for widely agreed (1) than for sickle disorders but questions still better venous access for adequate blood flow, and requirements for remain about optimal Hb levels, timing and frequency. Growth and physical activity while increasing intramedullary and Others are widely practiced as standard of care without ranextra-medullary erythroid expansion. Over transfusion may cause unnecessary iron loading and increased risk of extra-hepatic iron ly deposition .
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