Abstract
O-Silylation of N-acetylsultam 2 gives O-silyl- N, O-ketene acetal 3 which undergoes TiCl 4 promoted addition to aromatic and aliphatic aldehydes to afford, after flash chromatography, diastereomerically pure, crystalline aldols 5 which are readily converted to enantiomerically pure β-hydroxy carboxylic acids or esters.
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