Optically Active Nanomaterials for Bioimaging and Targeted Therapy.

Yu Yang,Li Wang,Xinxin Li,Bin Wan,Yuxin Gu

doi:10.3389/fbioe.2019.00320

Abstract

Non-invasive tracking for monitoring the selective delivery and transplantation of biotargeted agents in vivo has been employed as one of the most effective tools in the field of nanomedicine. Different nanoprobes have been developed and applied to bioimaging tissues and the treatment of diseases ranging from inflammatory and cardiovascular diseases to cancer. Herein, we will review the recent advances in the development of optics-responsive nanomaterials, including organic and inorganic nanoparticles, for multimodal bioimaging and targeted therapy. The main focus is placed on nanoprobe fabrication, mechanistic illustrations, and diagnostic, or therapeutical applications. These nanomedicine strategies have promoted a better understanding of the biological events underlying diverse disease etiologies, thereby facilitating diagnosis, illness evaluation, therapeutic effect, and drug discovery.

Highlights

Molecular imaging reflects biological information on temporal and spatial scales, unveiling the dynamics of disease (Smith and Gambhir, 2017)
The results demonstrated that the probes were mainly distributed in the cytoplasm
The primary tumor, and the residual tumor cells could be efficiently killed by activating host anti-tumor immunity and stimulating the immune memory, prohibiting distant metastasis. These findings suggest that nanocomplexbased photodynamic therapy (PDT) is an effective strategy for eliminating residual cells after tumor resection and preventing tumor recurrence and distant metastasis

Summary

Introduction

Molecular imaging reflects biological information on temporal and spatial scales, unveiling the dynamics of disease (Smith and Gambhir, 2017). We discuss recent progress in optical-sensitive NPs, their bioimaging involving fluorescence, luminescence, surface-enhanced Raman scattering (SERS), and photoacoustic (PA) signals, and their therapeutic applications in photodynamic therapy (PDT), photothermal therapy (PTT), and drug delivery.

Results

Conclusion