Abstract
A calcium-sensitive fluorescence sensor based on a fluorescent dye immobilized in a hydrogel that is placed onto the inner wall of a transparent measuring cell was developed. The ionized calcium (iCa)-sensitive fluorophore Oregon-Green bapta-1 dextran (OG-dextran) reacts with calcium ions, resulting in an increase in the fluorescence intensity that is proportional to the concentration of iCa. To measure the optical signal of the iCa-sensitive fluorescence sensor, an appropriate and very sensitive optical measuring device was developed. The aim of this sensor is to measure the iCa concentration during extracorporeal citrate–calcium anticoagulation in the extracorporeal blood circuit. Thus, the newly developed calcium sensor can offer an enhancement for the accurate online measurement of iCa during treatment and the adjustment of iCa afterwards.
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