Abstract
The manipulation of microbubbles by ultrasonic waves has the potential to be a useful technique in therapeutic ultrasound, such as for drug delivery systems and gene delivery systems. The Bjerknes force, which is an acoustic radiation force produced by microbubbles, acts as a driving force on the microbubbles; however, the two types of Bjerknes force make the resultant bubble movement very complex. In this paper, the evaluation of microbubble dynamics under ultrasonic wave radiation based on a laser diffraction method is proposed. The relationship between the microbubble spatial distribution and the diffracted light intensity is discussed on the basis of both theoretical analysis and numerical simulations. Experiments are carried out using ultrasonic wave contrast agent as microbubbles.
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