Abstract
In this paper, measurements of the optical properties (diffuse reflectance, total and collimated transmittance) of brain tissues in healthy rats and rats with C6-glioma were performed in the spectral range from 350 to 1800 nm. Using these measurements, characteristic tissue optical parameters, such as absorption coefficient, scattering coefficient, reduced scattering coefficient, and scattering anisotropy factor were reconstructed. It was obtained that the 10-day development of glioma led to increase of absorption coefficient, which was associated with the water content elevation in the tumor. However, further development of the tumor (formation of the necrotic core) led to decrease in the water content. The dependence of the scattering properties on the different stages of model glioma development was more complex. Light penetration depth into the healthy and tumor brain was evaluated.
Highlights
Gliomas are one of the most common types of primary brain tumors and the leading cause of death by brain diseases in both children and adults [1]
Tumors are graded (I, II, III, and IV) according to their anticipated biological behavior, from the least malignant to the most malignant: grade I has benign cytological features, grade II is characterized by moderate cellularity without anaplasia or mitotic activity, grade III has cellularity, anaplasia, mitoses, and grade IV is same as grade III plus microvascular proliferation and necrosis [6]
Our work extends spectral range available for analysis of optical properties of the brain tissue in healthy rats and rats with C6-glioma, which is an adequate model of human glioblastoma multiforme
Summary
Gliomas are one of the most common types of primary brain tumors and the leading cause of death by brain diseases in both children and adults [1]. The median survival of patients with gliomas of the brain ranges from 12 to 15 months [2,3,4]. In spite of the use of the most aggressive methods for the treatment of gliomas, survival benefit is only a few months [4]. The tumors classified as gliomas include a wide variety of histology [1]. To make the glioma diagnostics more objective, since 2016 World Health Organization (WHO) uses phenotypic and genotypic parameters for classification of glioma [5]. Clinical diagnosis of brain gliomas is crucial for success patients’ treatment
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