Abstract
We propose a new optical probe for near-infrared (NIR) fluorescence signal detection with high optical performance and thermal stability. The optical probe is composed of an optical source part for efficient excitation of NIR fluorescence signal, a heat dissipation part for stable operation of the NIR fluorescence probe, and an optical detection part for efficient detection of NIR fluorescence signal. From a simulation by use of an optical simulation tool, Light ToolsTM, we could confirm that the optical probe has optical propagation efficiency of 79.6% in case of using a circular detector with 20 cm in diameter located at 20 cm in distance from the optical source. From a measurement of temperature variation of the optical probe, we could also confirm that the optical probe has thermal stability with a standard deviation of 2.19°C under room temperature condition. Finally, from an evaluation of fluorescence image quality, we could confirm that an optical noise which can bring on by overlapped band between optical spectrum of the optical source for fluorescence excitation and optical spectrum of the emitted fluorescence signal decreased effectively in the optical probe.
Highlights
NIR fluorescence imaging has been used to improve sentinel lymph node (SLN) mapping in breast cancer patients, to assess the extent of colorectal metastases during curative-intended surgery and so on because NIR has relatively low absorption and scattering rates in hemoglobin, water and lipid [1]-[8]
We propose an optical probe for NIR fluorescence signal detection with high optical performance and thermal stability by making up for the weakness and strengthening the strength of LEDs with high optical power in the optical probe
Propagation efficiency of light in the optical probe was improved by use of an array of LEDs, a mirror, and collimating lenses
Summary
NIR fluorescence imaging has been used to improve sentinel lymph node (SLN) mapping in breast cancer patients, to assess the extent of colorectal metastases during curative-intended surgery and so on because NIR has relatively low absorption and scattering rates in hemoglobin, water and lipid [1]-[8]. (2014) Optical Probe for Near-Infrared (NIR) Fluorescence Signal Detection with High Optical Performance and Thermal Stability. LEDs come into the spotlight as light sources for medical use because LEDs with high power (more than 1 watt) have been developed recently. Optical power of LEDs has been improved, LEDs still have weaknesses to be considered in medical application such as heat, broad divergence angle, relatively broad spectrum and so on. We propose an optical probe for NIR fluorescence signal detection with high optical performance and thermal stability by making up for the weakness and strengthening the strength of LEDs with high optical power in the optical probe
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