Abstract
Stress is a major factor for a risk of cerebrovascular catastrophes. Studying of mechanisms underlying stress-related brain-injures in neonates is crucial for development of strategy to prevent of neonatal stroke. Here, using a model of sound-stress-induced intracranial hemorrhages in newborn rats and optical methods, we found that cerebral veins are more sensitive to the deleterious effect of stress than arteries and microvessels. The development of venous insufficiency with decreased blood outflow from the brain accompanied by hypoxia, reduction of complexity of venous blood flow and high production of beta-arrestin-1 are possible mechanisms responsible for a risk of neonatal hemorrhagic stroke.
Highlights
IntroductionNeonatal stroke is among the top ten causes of death (mortality rate is approximately 25%) in newborns [1]
Neonatal stroke is among the top ten causes of death in newborns [1]
The development of venous insufficiency with decreased blood outflow from the brain accompanied by hypoxia, reduction of complexity of venous blood flow and high production of beta-arrestin-1 are possible mechanisms responsible for a risk of neonatal hemorrhagic stroke
Summary
Neonatal stroke is among the top ten causes of death (mortality rate is approximately 25%) in newborns [1]. The incidence of neonatal stroke in term newborns is commonly referred to as 1.17/1000 live births [4, 6]. The long-term clinical observations in small patients who were diagnosed suggest that in further life, major cognitive deficit develops in more than 50% of neonates after the stroke and approximately 75% of such babies need special education in school [10,11,12,13]. Neonatal stroke is a major problem of future generation’s health due to the high rate of death and cognitive disability of newborns after the stroke. The study of hidden mechanisms underlying the silent pathological processes preceding and accompanying the stroke in neonates is absolutely essential
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