Abstract
Integration of functional nanomaterials with optical micro/nanofibers (OMNFs) can bring about novel optical properties and provide a versatile platform for various sensing applications. OMNFs as the key element, however, have seldom been investigated. Here, we focus on the optimization of fiber diameter by taking micro/nanofiber-based localized surface plasmon resonance sensors as a model. We systematically study the dependence of fiber diameter on the sensing performance of such sensors. Both theoretical and experimental results show that, by reducing fiber diameter, the refractive index sensitivity can be significantly increased. Then, we demonstrate the biosensing capability of the optimized sensor for streptavidin detection and achieve a detection limit of 1 pg/mL. Furthermore, the proposed theoretical model is applicable to other nanomaterials and OMNF-based sensing schemes for performance optimization.
Highlights
In recent years, there is a growing need for fast, reliable, and highly sensitive testing systems in the field of environmental monitoring, food safety, drug development, biomedical research, and clinical diagnosis
Our analysis shows thatbased by optimizing diameter of the optical micro/nanofibers (OMNFs), the refractive index (RI)
We use the Langmuir isotherm model (Equation (6)) to describe the reaction system where streptavidin molecules bind to immobilized biotin, since the output optical signal scales with the surface coverage [35]
Summary
There is a growing need for fast, reliable, and highly sensitive testing systems in the field of environmental monitoring, food safety, drug development, biomedical research, and clinical diagnosis. Integrating plasmonic withcross-section optical fibers enhance the light–matter are rather limited, due to thenanoparticles small extinction of to a single nanoparticle, and theinteraction relatively is a smart strategy to enhance the plasmonic sensing ability. This sensor scheme can realize remote large area of a free space light beam. ∆A/RIU [22], and the limits enhance the photon-to-plasmon conversion efficiency, aiming at improving the sensitivity These of detection (LOD) are normally several tens of pM level [23]. Several studies tried to optimize sensors include the optical fiber geometry to expose more optical power into the evanescent field to enhance the.
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