Abstract
As an attempt to develop a sensitive device for biomolecule detection, a micromechanical methodology, based on the rheological change of an air/water interface is put forward [1]. Capillary waves induced from the vertical electrodynamic vibration of a brimfull cylindrical tank, filled with water, stand as a good way to identify dilational elasticity and viscosity of an ageing interface. Of prior interest for us, the complex wave number and the frequency of the waves are obtained through an optical technique, which allow us to recognise accurately the whole interface geometry. These two parameters and a modeling based on a dispersion relation are jointly used to identify the dilational rheology of the interface [2]. The validity of the methodology is assessed making use of palmitic acid as surfactant.
Highlights
Detection and characterization of biological material is currently identified as a priority in biotechnology
We present a drastically different technique based on the rheological properties of a functionalized air/water interface to which biomolecules adsorb [1]
It is worth evoking the hybridization of solubilized target-DNAstrands on receptor-DNA-strands initially adsorbed to a lipidic monolayer spread over an air/water interface
Summary
Detection and characterization of biological material is currently identified as a priority in biotechnology. Up to now most attention has been focused on biochips [3]. We present a drastically different technique based on the rheological properties of a functionalized air/water interface to which biomolecules adsorb [1]. It is worth evoking the hybridization of solubilized target-DNAstrands on receptor-DNA-strands initially adsorbed to a lipidic monolayer spread over an air/water interface. The surface pressure of the interface is proved to be sensitive to the hybridization process [4]. This paper aims at developing a rheological diagnostic based on the elongation of a functionalized air/water interface and which is expected to be more sensitive than a surface pressure measurement, alone
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