Optical imaging of cervical precancerous lesions based on active stereo vision and motion tracking

Tao T Wu,So-Fan Yim,Jianan Y Qu,Tak-Hong Cheung

doi:10.1364/oe.16.011224

Abstract

A 3-D optical imaging system based on active stereo vision and motion tracking is built to track the motion of patient and to register the time-sequenced images of cervix recorded during colposcopy. The imaging system is evaluated by examining human subjects in vivo before routine colposcopy examination procedures. The system tracks the motion of patient accurately. The temporal kinetics of the acetowhitening process in the area of interest can be quantitatively measured. The results demonstrate that the kinetics of acetowhitening may be potentially used for accurately differentiating the precancerous lesions from the normal and benign lesions, and grading the precancerous lesions.

Highlights

Colposcopy is a standard technique to detect early neoplastic growth in cervical tissue
A 3-D optical imaging system based on active stereo vision and motion tracking is built to track the motion of patient and to register the time-sequenced images of cervix recorded during colposcopy
The imaging system is evaluated by examining human subjects in vivo before routine colposcopy examination procedures

Summary

Introduction

Colposcopy is a standard technique to detect early neoplastic growth in cervical tissue. The 3-D surfaces of a cervix model measured at different times are used to track the motion and to register the time-sequenced 2-D images. We demonstrated that this imaging system holds the potential to enable quantitative mapping of acetowhitening kinetics over the cervical surface. The goals of this study are twofold: (i) to evaluate the accuracy of tracking patient’s motion and co-registration of the time-sequenced 2-D images of cervix recorded during colposcopy in vivo, (ii) to demonstrate that the temporal kinetics of acetowhitening in the imaged tissue can be quantitatively mapped based on the co-registered time-sequences images of cervix

Objectives

Results

Conclusion