Abstract
We demonstrate an optical method for detecting specific binding events in an oligo deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC) as a result of DNA hybridization. A homeotropic orientation of the NLC supported by oligoDNA changes to a random planar orientation after hybridization. Such DNA hybridization and subsequent NLC reorientation are easily observable with a simple detection system via long-range orientational order and large optical anisotropy of the NLC.
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