Abstract
Summary and ConclusionIn 13 trials in 9 dogs, when the intact tibias were perfused by way of the femoral artery with blood and cardio-green dye at a constant rate (set to maintain equivalent blood pressure), the average pulsatile OD activity was 0.21 ± 0.03% and 0.15 ± 0.04%, respectively, when compared to the total OD change seen with the perfusion of the bone with saline. These results indicate that the majority of the pulsatile activity was due to volume changes within the bones' vascular system and not due to flow-related phenomena. When in six dogs, 24 injections of acetylcholine (60–90 μg) and 26 injections of norepinephrine (8–10 μg) were made into the femoral artery under constant flow conditions, the mean maximum total OD decreased 16% and 18%, respectively. These changes were most probably due to changes in the bone vascular volume.The authors wish to thank Miss Paula Phillips, Mr. James Bland, and Miss Sandra Hershberger for their fine technical assistance.
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