Abstract
Membrane receptors transmit external signals into cells in response to extracellular stimuli and their activities are controlled spatiotemporally. In recent years, it has become possible to control activity of a target membrane receptor by external light using a photoreceptor protein. It forms oligomers or interacts specifically with its binding partners after light absorption. Controlling receptor activities by external light is now a powerful approach to elucidating the role of receptor activities and its dynamics in various life phenomena. In this review, we describe a new technology of optically controllable receptor using a photoreceptor protein, CRY2, and its application to the interaction of GPCR with β-arrestin in living cells.
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