Abstract
To demonstrate the feasibility of performing optical coherence tomography of the human larynx on the awake patient with a novel flexible fiberoptic delivery system. Prospective clinical trial. Imaging was performed in 17 awake patients. A flexible optical coherence tomography probe was inserted through the nose and placed in near or gentle contact with laryngeal tissues under direct endoscopic visualization. Images were successfully obtained from all laryngeal subsites and clearly identified laryngeal mucosal microanatomy. Several critical probe design modifications improved rotational and angular control of the distal tip while allowing linear translation of the probe and allowing more accurate apposition of the probe onto target tissues, which is critical for transnasal laryngeal imaging. This study demonstrates the feasibility of awake transnasal laryngeal optical coherence tomography and identifies key instrumentation needed to obtain useful images.
Highlights
Images were successfully obtained from all laryngeal subsites and clearly identified laryngeal mucosal microanatomy
This study demonstrates the feasibility of awake transnasal laryngeal optical coherence tomography and identifies key instrumentation needed to obtain useful images
The vocal fold consists of three anatomic layers, the epithelium, the lamina propria (LP), and the thyroary-tenoid muscle
Summary
The details of the core time-domain OCT device used in this study have been described previously and are summarily described here. The system in this study used a lowcoherence light source (central wavelength λ = 1310 nm; JDS Uniphase, San Jose, CA).. Raster scanned images were generated by controlled motion of the imaging fiber with a precision piezoelectric translation stage (model 663.4pr; Physik Instrumente, Tustin, CA). The axial resolution of the imaging system is determined by the coherence length of the light source and is approximately 7 μm. The lateral resolution is determined by diffraction and is approximately 10 μm. Signals were obtained up to a depth of 1.6 mm, whereas the lateral extent of each image was determined by the length over which the fiber was translated by the translation stage, typically 6 mm
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