Abstract
PurposeTo investigate the thickness of retinal layers and association with final visual acuity using spectral-domain optical coherence tomography (SD-OCT) in macular area of macula-off rhegmatogenous retinal detachment (RRD) patients after a successful macular re-attachment.MethodsIn retrospective study, a total 24 eyes with macula-off RRD were enrolled. All patients underwent vitrectomy to repair RRD. Outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor layer (PR), retinal pigment epithelium (RPE) thicknesses were measured by the Spectralis (Heidelberg Engineering, Heidelberg, Germany) SD-OCT with automated segmentation software. The relationship between the thicknesses of each retinal layer and postoperative logarithm of the minimum angle of resolution scale (LogMAR) visual acuity was analyzed.ResultsOPL and RPE thicknesses were not significantly different between the retinal detachment eyes and fellow eyes (P = 0.839, 0.999, respectively). The ONL and photoreceptor thickness were significantly thinner in the retinal detachment eyes (P <0.001 and 0.001, respectively). In the univariate regression analysis, preoperative best corrected visual acuity (BCVA), ONL thickness and photoreceptor thickness showed association with the postoperative BCVA (P = 0.003, <0.001 and 0.024, respectively). In final multiple linear regression model, ONL thickness was the only variable significantly associated with postoperative BCVA (P = 0.044).ConclusionsSegmented ONL and photoreceptor thickness of retinal detachment eyes were significantly thinner than fellow eyes. Segmental analysis of the retinal layer in macular region may provide valuable information for evaluation RRD. And ONL thickness can be used as a potential biomarker to predict visual outcome after RRD repair.
Highlights
Rhegmatogenous retinal detachment (RRD) is the most common type of retinal detachment
Segmented outer nuclear layer (ONL) and photoreceptor thickness of retinal detachment eyes were significantly thinner than fellow eyes
ONL thickness can be used as a potential biomarker to predict visual outcome after RRD repair
Summary
Rhegmatogenous retinal detachment (RRD) is the most common type of retinal detachment. RRD is caused by the movement of liquefied vitreous gel into the subretinal space through a retinal break driven by vitreoretinal traction and sequential separation of sensory retina and retinal pigment epithelium (RPE) [1]. The annual incidence of RRD is known to be about 10.5 people per 100,000 population [2]. The goal of RRD repair is to close the retinal break, eliminate the vitreous traction and enable re-attachment of detached retina. Even after successful retinal reattachment, many patients complain of incomplete visual acuity, abnormal color perception and metamorphopsia [6,7,8]. It is difficult to determine the presence of complete anatomic reattachment and change in the macula using only funduscopic examination
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
