Optical Coherence Tomography Angiography Morphology following Rhegmatogenous Retinal Detachment Repair: ALIGN Post-Hoc Analysis.

Abstract

To compare foveal avascular zone (FAZ) geometric indices using optical coherence tomography angiography (OCTA) in pneumatic retinopexy (PnR) vs pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD). FAZ morphology was assessed as a possible imaging feature of retinal displacement. ALING post-hoc analysis included primary fovea-off RRDs that underwent successful PnR or PPV and OCTA and FAF at 3 months postoperatively, at St. Michael's Hospital, Toronto, Canada. FAZ area(mm2), axial ratio, circularity, and roundness were measured and FAF images were assessed for displacement. 72 patients were included, 78%(56/72) male, mean age of 60±9 years and 60%(43/72) phakic. 65%(47/72) and 35%(25/72) underwent PnR and PPV, respectively. Mean logMAR baseline visual acuity was 1.49±0.76. FAZ circularity was lower following PPV(0.629±0.120) versus PnR(0.703±0.122);p=0.016. 66 patients had gradable FAFs. Retinal displacement was present in 29%(19/66), 84.2%(16/19) of which had macular displacement. FAZ circularity was lower in eyes with macular displacement(0.613±0.110) versus those without displacement(0.700±0.124);p=0.015. There was a moderate negative correlation between 12-month aniseikonia and FAZ circularity(r=-0.262;p=0.041). FAZ circularity was lower following PPV and in eyes with macular displacement, and it was negatively correlated with 12-month aniseikonia scores. FAZ circularity may be another imaging feature to consider postoperatively following RRD repair.