Abstract
To investigate retinal microvasculature changes in patients treated with anti-VEGF for macular edema secondary to branch retinal vein occlusion. We examined 38 eyes of 19 patients for the study. We measured superficial and deep capillary plexus vessel densities (%), foveal avascular zone areas (mm2), and central macular thicknesses. Parafoveal superficial and deep capillary plexus values were significantly lower in eyes with branch retinal vein occlusion than in fellow eyes (p<0.001). We found a significant increase in parafoveal deep capillary plexus values after the anti-VEGF treatment (p=0.032). The mean foveal avascular zone was larger in eyes with branch retinal vein occlusion than in control eyes (p<0.001). The mean central macular thickness was significantly higher in eyes with branch retinal vein occlusion than in controls, and we observed a significant decrease in central macular thickness after anti-VEGF treatment (<0.001). In addition, the cystic structures in the deep capillary plexus regressed. Optical coherence tomography angiography enables qualitative and quantitative evaluations during follow-up of patients treated for branch retinal vein occlusion.
Highlights
Retinal vein occlusion (RVO) is the most common cause of retinal vascular disease after diabetic retinopathy
We investigated retinal superficial and deep vessel densities (VDs) and foveal avascular zone (FAZ) areas using Optical coherence tomography angiography (OCTA) in patients with branch retinal vein occlusions (BRVOs) complicated by macular edema at baseline and after intravitreal anti-VEGF treatments
When compared with the unaffected eyes of the patients before treatment, we found the FAZ areas in BRVO eyes to be significantly larger than those in the fellow eyes
Summary
Retinal vein occlusion (RVO) is the most common cause of retinal vascular disease after diabetic retinopathy. The most important cause of visual impairment in RVO is macular edema[1]. Fundus fluorescein angiography (FFA) and optical coherence tomography (OCT) devices can be used to diagnose RVO and to monitor clinical findings and treat ment response. SD-OCT is the most useful device for identifying. This content is licensed under a Creative Commons Attributions 4.0 International License. It allows the evaluation of individual retinal layers, and it is used to evaluate macular edema changes after treatment[2,3,4,5]
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