Optical cardiac and respiratory device for synchronized MRI on small animal

Abstract

Respiratory and cardiac motion must be overcome if MRI of the thorax or abdomen is to be performed satisfactorily. An optical-based device designed to synchronize MRI acquisition on small animal was developed using a pair of optical fibers. Light from a laser diode was focused into the transmit fiber and impinged upon the moving skin. The reflected light was detected by the receive fiber and then caries to a light-voltage photodiode, were the signal was amplified and filtered. The recorded optical-based signals are well correlated with both respiratory and heart motions. The signal amplitude recorded on both rats and mice were large enough to perform an easy adjustment of gating level with good differentiation between cardiac and respiratory signal. The device developed using thin fibers is simple to use even when space available around the mice is limited (narrow coils). The signal is totally unaffected by radiofrequency impulsions or magnetic field gradients used for imaging. This optical-based trigger system was used successfully for dual cardiac and respiratory synchronization of rat and mice for heart and liver examinations at 4.7T.