Abstract
A novel optical label-free bio-sensing platform based on a new class of resonances supported in a photonic crystal metasurface is reported herein. Molecular binding is detected as a shift in the resonant wavelength of the bound states in the continuum of radiation modes. The new configuration is applied to the recognition of the interaction between protein p53 and its protein regulatory partner murine double minute 2 (MDM2). A detection limit of 66 nM for the protein p53 is found. The device provides an excellent interrogation stability and loss-free operation, requires minimal optical interrogation equipment and can be easily optimized to work in a wide wavelength range.
Highlights
Optical biosensors are widely-used devices that find many crucial applications such as health-care, pharmaceutical and food quality control, environmental analysis, security, and industrial and chemical process monitoring [1,2,3,4]
When the protein murine double minute 2 (MDM2) linked over the photonic crystals (PhCs) surface, a local modification in the refractive index occurred
The shift was produced by the perturbation of the dielectric environment that induces a redistribution of the electromagnetic field, which was pushed towards the region of higher refractive index
Summary
Optical biosensors are widely-used devices that find many crucial applications such as health-care, pharmaceutical and food quality control, environmental analysis, security, and industrial and chemical process monitoring [1,2,3,4]. Due to their high specificity, sensitivity, small size, and low cost, optical biosensors offer great advantages over conventional detection techniques, allowing the direct and real-time identification of many biochemical molecules. A widespread class of label-free photonic biosensors exploits optical resonance effects They experience a shift in the resonance wavelength (λ) in response to a change of the RI of the medium (generally a dielectric) surrounding the sensing area.
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