Abstract
PurposeTo evaluate changes in cup/disc (C/D) diameter ratios and parapapillary atrophy in patients with non-arteritic anterior ischemic optic neuropathy (NA-AION), using morphometric methods.MethodsThe clinical non-interventional study included 157 patients with unilateral or bilateral NA-AION. Optic disc photographs taken from both eyes at the end of follow-up were morphometrically examined.ResultsFollow-up was 86.3±70.3 months. Horizontal and vertical disc diameters (P = 0.30;P = 0.61, respectively), horizontal and vertical C/D ratios (P = 0.47;P = 0.19,resp.), and size of alpha zone and beta zone of parapapillary atrophy (P = 0.27;P = 0.32,resp.) did not differ significantly between affected eyes and contralateral normal eyes in patients with unilateral NA-AION. Similarly, horizontal and vertical disc diameters, horizontal and vertical C/D ratios, and size of alpha zone and beta zone did not vary significantly (all P>0.05) between the unaffected eyes of patients with unilateral NA-AION and the eyes of patients with bilateral NA-AION. Optic disc diameters, C/D ratios, size of alpha zone or beta zone of parapapillary atrophy were not significantly associated with final visual outcome in the eyes affected with NA-AION (all P>0.20) nor with the difference in final visual acuity between affected eyes and unaffected eyes in patients with unilateral NA-AION (all P>0.25).ConclusionsNA-AION did not affect C/D ratios nor alpha zone and beta zone of parapapillary atrophy. Optic disc size was not related to the final visual acuity outcome in NA-AION.
Highlights
Non-arteritic anterior ischemic optic neuropathy (NA-AION) is an acute ischemic disorder of the optic nerve head [1], occurring with an incidence rate of about 2 to 10 per 100,000 subjects [2,3,4,5]
Whether final visual outcome in the affected NA-AION eyes is associated with the optic disc diameter, cup/disc diameter (C/ D) ratio, or size of alpha zone or beta zone of parapapillary atrophy
Optic Disc Diameters In patients with unilateral NA-AION (n = 70), comparing the affected eyes with the unaffected contralateral eyes revealed that the horizontal disc diameter (P = 0.30) and the vertical disc diameter (P = 0.61) did not differ significantly (Table 1)
Summary
Non-arteritic anterior ischemic optic neuropathy (NA-AION) is an acute ischemic disorder of the optic nerve head [1], occurring with an incidence rate of about 2 to 10 per 100,000 subjects [2,3,4,5]. The association of NA-AION with absent or a small cup/ disc ratio (C/D) has been reported by several studies since 1974 [6,7,8,9,10,11,12,13,14,15,16,17,18,19,20], little information on the following aspects about NAAION has been gathered so far: 1. 3. Whether final visual outcome in the affected NA-AION eyes is associated with the optic disc diameter, cup/disc diameter (C/ D) ratio, or size of alpha zone or beta zone of parapapillary atrophy. The objective of the present study was, to investigate the above aspects of NA-AION eyes by measuring the optic nerve head by a morphometric method in a larger number of patients with: (i) unilateral NA-AION and (ii) bilateral NA-AION, several months after the acute onset of the disorder, when the optic disc edema had resolved
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
