Abstract
Abstract Patients with subacute bacterial endocarditis demonstrated high titers of specific opsonic, agglutinating, and complement-fixing antibodies for the infecting organisms. Heat-stable specific antibodies were effective opsonins, and the opsonic activity of serum was found to be a more sensitive index of antibody response than were agglutinating or complement-fixing activities. The 7S serum fraction from all of the patients with subacute bacterial endocarditis demonstrated opsonic, agglutinating, and complement-fixing antibody activity. In contrast, 19S serum fractions showed agglutinating and complement-fixing antibody activities, but, with one exception, there was no measurable opsonic activity. In normal sera, heat-labile factors appeared to play the major opsonic role with the bacterial species studied. In patients with subacute bacterial endocarditis the 7S immunoglobulin fractions demonstrated maximum opsonic activity.
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