Abstract
Neuropeptide Y is colocalised with noradrenaline in the locus coeruleus (LC). This study evaluated the effects of neuropeptide Y (NPY) Y1 and Y2 receptor agonists on the hypnotic response to α2-agonist dexmedetomidine following the unilateral microinjection of these drugs into the vicinity of the locus coeruleus (LC). Dexmedetomidine alone (1 μg) induced a loss of righting reflex and sleep in all animals. [Leu31,Pro34]NPY (10 pmol) lengthened, whereas NPY13-36 (100 pmol) shortened the time of latency to sleep. The duration of sleep was shortened in rats pretreated with [Leu31,Pro34;rsqb;NPY. These data demonstrate that the hypnotic effect to dexmedetomidine in the LC can be modulated differentially by Y1 and Y2 receptor-selective agonists and provde additional evidence for NPY/α2-adrenoceptor interaction in this brain area.
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