Year-end Sale % OFF 
Abstract
Background Both particulate (pGC) and soluble guanylyl cyclases (sGC) synthesize cGMP. While sGC is activated by nitric oxide (NO), pGC is activated by natriuretic peptides (NPs) such as ANP or BNP. Physiological effects of cGMP are mainly mediated by cGMP-dependent protein kinase (PKG) and cGMP phosphodiesterases (PDEs), namely PDE2 and PDE5. We hypothesised that PKG may underlie regulatory feedback in cGMP signals produced by pGC and sGC activation in adult rat ventricular myocytes (ARVMs).
Highlights
Both particulate and soluble guanylyl cyclases synthesize cGMP
We hypothesised that PKG may underlie regulatory feedback in cGMP signals produced by pGC and soluble guanylyl cyclases (sGC) activation in adult rat ventricular myocytes (ARVMs)
KT decreased the ICNG current stimulated by ANP (10 nM and 100 nM) in a PDE-independent manner, but had no effect on total cGMP content measured by radioimmunoassay, which is controlled by PDE2 and PDE5 subtypes
Summary
Published: 25 July 2007 BMC Pharmacology 2007, 7(Suppl 1):P10 doi:10.1186/1471-2210-7-S1-P10. 3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
