Abstract
Dopamine hyperpolarizes growth hormone-producing cells (GHC) in the CNS of Lymanea stagnalis. This effect of dopamine was mimicked by the D-2 receptor agonist LY 141865 and antagonized by the D-2 receptor antagonists (−) sulpiride and YM 09151-2. SKF 38393, a selective D-1 receptor aagonist, increased the excitability of the GHC. This effect was mimicked by intracellular injection of cyclic AMP andantonized by the D-1 receptor antagonist SCH23390. Dopamine (in the presence of (−)-sulpride) also increased the excitability of the GHC. It is concluded that both a D-1 and a D-2 receptor regulate the electrical activity of the GHC in the CNS of Lymnaea stagnalis.
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