Abstract
The basal ganglia have been implicated in action selection and timing, but the relative contributions of the striatonigral (direct) and striatopallidal (indirect) pathways to these functions remain unclear. We investigated the effects of optogenetic stimulation of D1+ (direct) and A2A+ (indirect) neurons in the ventrolateral striatum in head-fixed mice on a fixed time reinforcement schedule. Direct pathway stimulation initiates licking, whereas indirect pathway stimulation suppresses licking and results in rebound licking after stimulation. Moreover, direct and indirect pathways also play distinct roles in timing. Direct pathway stimulation produced a resetting of the internal timing process, whereas indirect pathway stimulation transiently paused timing, and proportionally delayed the next bout of licking. Our results provide evidence for the continuous and opposing contributions of the direct and indirect pathways in the production and timing of reward-guided behavior.
Highlights
The striatum is the major input nucleus of the basal ganglia (BG) and contains two major populations of medium spiny projection neurons (Gerfen et al, 1990; Mink, 1996)
We previously showed that opponent classes of substantia nigra pars reticulata (SNr) projection neurons command downstream position control systems in the midbrain and brainstem to move the
We show that direct pathway stimulation in the ventrolateral striatum (VLS) can initiate licking, whereas indirect pathway stimulation can suppress ongoing licking, and that these pathways can work in concert to continuously regulate ongoing licking
Summary
The striatum is the major input nucleus of the basal ganglia (BG) and contains two major populations of medium spiny projection neurons (Gerfen et al, 1990; Mink, 1996). Ever since the connectivity of these pathways was defined, there has been controversy on their contributions to behavior Given their opposite effects on BG output, an influential model of the striatum casts the direct and indirect pathways in opposing roles with the direct pathway promoting behavior and the indirect pathway suppressing behavior (Albin et al, 1989; Freeze et al, 2013; Kravitz et al, 2010). This view has been questioned by studies that described concurrent activation of these two populations during behavior, suggesting complementary contributions of these two pathways (Cui et al, 2013; Isomura et al, 2013)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
