OPN gene polymorphisms are associated with susceptibility and clinicopatholigical characteristics of cervical cancer in a Chinese cohort

Abstract

To explore the possible association between Osteopontin (OPN) genetic polymorphisms and cervical cancer risk, which remains undocumented yet. We enrolled 300 patients with histologically confirmed cervical squamous cell carcinoma and 774 age-matched healthy, unrelated, cancer-free female healthy subjects as control subjects. Three OPN gene polymorphisms were determined. Reulsts: The genotype distributions and allele frequencies of -156 GG/G and -443 T/C polymorphisms were significantly differed between cervical cancer patients and controls. The cervical cancer cases had markedly higher percentage of -156 GG carriage and significantly lower TT and TC of -443 genotypes than controls. The Logistic regression analysis showed that the -156 GG carriage was associated with significantly elevated OR of 2.492 for cervical cancer while the TT and TC of -443 represented lower risks. This trend was not seen in subjects without human papillomavirus infections. In addition, the -156 GG carriages was significantly associated with poorer clinical conditions, including higher clinical stage, poorer tumor differentiation, higher positive lymph node status and higher chance of parametrical invasion. The -443 T/C and -66 T/G polymorphisms did not show any association with the clinicopathological feature. These results suggest that the -156 GG/G and -443T/C polymorphisms might be used as a genetic marker for cervical cancer susceptibility.